YANSS 346 – The science behind the nocebo effect and how the suffering can be real, but the source may not be what you assume

The suffering is real, but the source may not be what you assume. That’s the essence of the nocebo effect, the placebo effect’s evil twin. As neuroscientist Dr. Helen Pilcher explains, illness is not simply a matter of biology. Our thoughts, conscious or otherwise, can make lead to symptoms in unexpected ways.


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“Illness is not simply a matter of biology. Our thoughts, conscious or otherwise, can make us feel pain or become unwell. If you experienced side effects from your Covid vaccine, the chances are that these were caused by your belief that you would experience them. When a nurse tells you ‘this is going to hurt’, it generally does – but perhaps it shouldn’t…”

In this revelatory study, neuroscientist Helen Pilcher explores the hidden impact of the ‘nocebo effect’ – the placebo’s evil twin. Medical studies have proven the nocebo effect to cause pain, nausea, paralysis, seizures, and even blindness.

The nocebo effect impacts how we grow sick and grow old, explains why people who don’t have food allergies have dietary intolerances, and why, during the pandemic, so many teenagers caught tics through social media. From Havana Syndrome to hex deaths, chronic pain and mystery illnesses, this book explains what happens when illness, psychology and society meet – and shows us what we can do to become less ill and more well.

‘Absolutely fascinating’ Dr Julie Smith, author of the #1 Sunday Times bestseller, Why Has Nobody Told Me This Before?

‘Entrancing’ David Robson, author of the Sunday Times bestseller The Expectation Effect

Helen Pilcher


Dr Helen Pilcher is an author, speaker and science communication consultant. She likes drinking tea and writing books about science. Helen is also a recovering neuroscientist and lapsed stand-up comedian. She has the love of a genetically modified wolf called Higgs.


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